Table 2

Levels of free and sulphated steroids in whole adult 40,XY and 39,XY*O mouse brain (n = 4 per group)
Steroid (systematic name in brackets) Free steroids Steroid sulphates
40,XY Concentration (ng/g) 39,XY*O Concentration (ng/g) Significance t6 40,XY Concentration (ng/g) 39,XY*O Concentration (ng/g) Significance t6
Androsterone (5α-androstan-3α-ol-17-one) ND; < 4.56 ND; < 4.56 N/A ND; < 0.63 ND; < 0.63 N/A
dehydroepiandrosterone (5-androsten-3β-ol-17-one) 36.15 ± 9.74 32.91 ± 15.21 0.18, P = 0.86 0.51 ± 0.02 0.53 ± 0.01 −1.34, P = 0.23
Epiandrosterone (5α-androstan-3β-ol-17-one) 2.80 ± 0.12 3.60 ± 0.44 −1.77, P = 0.13 0.71 ± 0.02 0.72 ± 0.01 −0.66, P = 0.54
Androstenediol (5-androsten-3β,17β-diol) ND; < 0.01 ND; < 0.01 N/A ND; < 0.45 ND; < 0.45 N/A
17β-oestradiol(1,3,5(10)-oestratrien-3,17β-diol) ND; < 0.53 ND; < 0.53 N/A ND; < 0.05 ND; < 0.05 N/A
Testosterone (4-androsten-17β-ol-3-one) 19.64 ± 2.27 19.63 ± 9.81 0.00, P = 1.00 ND; < 1.77 ND; < 1.77 N/A
Allopregnanolone (5α-pregnan-3α-ol-20-one) 1.47 ± 0.27 1.95 ± 0.77 −0.59, P = 0.58 ND; < 0.01 ND; < 0.01 N/A
Allopregnanediol (5α-pregnan-3α,20α-diol) ND; < 0.01 ND; < 0.01 N/A ND; < 0.01 ND; < 0.01 N/A
Pregnenolone (5-pregnen-3β-ol-20-one) 31.26 ± 13.37 25.12 ± 15.05 0.31, P = 0.77 ND; < 0.01 ND; < 0.01 N/A
Epiallopregnanolone (5α-pregnan-3β-ol-20-one) 17.07 ± 5.13 25.25 ± 17.19 −0.46, P = 0.67 ND; < 0.37 ND; < 0.37 N/A
5α-dihydroprogesterone (5α-pregnan-3,20-dione) 12.75 ± 5.26 15.01 ± 6.16 −0.28, P = 0.79 ND; < 0.01 ND; < 0.01 N/A
20β-dihydropregnenolone (5-pregnen-3β,20β-diol) ND; < 3.10 ND; < 3.10 N/A ND; < 0.01 ND; < 0.01 N/A
20α-dihydropregnenolone (5-pregnen-3β,20α-diol) 0.91 ± 0.11 0.94 ± 0.09 −0.21, P = 0.84 ND; < 0.01 ND; < 0.01 N/A
Progesterone (4-pregnen-3,20-dione) 3.74 ± 0.34 5.84 ± 2.05 −1.01, P = 0.35 ND; < 4.41 ND; < 4.41 N/A
5α,20α-tetrahydroprogesterone (5α-pregnan-20α-ol-3-one) 3.71 ± 0.22 3.97 ± 0.48 −0.50, P = 0.64 ND; < 1.61 ND; < 1.61 N/A

N/A not applicable, ND not detectable.

Trent et al.

Trent et al. Molecular Autism 2014 5:21   doi:10.1186/2040-2392-5-21

Open Data