Correlation analyses of 15q11-q13 copy number and transcript levels. The relationship between the number of genomic copies of 15q11-q13 and transcript levels in all cases showed a predictive positive correlation with GABAA receptor β3 (GABRB3) (a) and ubiquitin ligase 3A (UBE3A) (b), but a negative correlation with small nucleoriboprotein N (SNRPN) (c). Significance was calculated by simple regression analysis. Diamond, duplication of 15q11-q13; triangle, autism; square, control.
Scoles et al. Molecular Autism 2011 2:19 doi:10.1186/2040-2392-2-19