Table 1 |
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|
Clinical characteristics of the normal controls and subjects with autism.a |
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|
Control group (n = 34) |
Autism group (n = 32) |
P-value |
|
|
|
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|
Age, years |
12.4 ± 2.6 (6 to 18) |
12.3 ± 3.2 (6 to 18) |
NS |
|
Weight, kg |
42.3 ± 14.3 (15.6 to 89.3) |
41.8 ± 15.0 (17.5 to 96.6) |
NS |
|
Height, cm |
150.8 ± 14.8 (111 to 174) |
148.7 ± 17.9 (110 to 178) |
NS |
|
BMI, kg/m2 |
18.1 ± 3.5 (12.7 to 32.4) |
18.3 ± 3.1 (13.9 to 30.5) |
NS |
|
ADI-R |
|||
|
Domain A score |
- |
20.2 ± 4.9 (10 to 27) |
- |
|
Domain BV score |
- |
13.6 ± 3.9 (8 to 21) |
- |
|
Domain C score |
- |
5.4 ± 2.0 (3 to 9) |
- |
|
Domain D score |
- |
3.1 ± 1.0 (2 to 5) |
- |
|
WISC-III |
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|
Verbal IQ |
- |
91.3 ± 21.6 (48 to 133) |
- |
|
Performance IQ |
- |
95.3 ± 21.1 (47 to 131) |
- |
|
Full-scale IQ |
- |
91.0 ± 23.2 (44 to 134) |
- |
|
Anterior pituitary hormones |
|||
|
ACTH, pg/mL |
7.2 ± 3.1 (3.7 to 14.2) |
11.6 ± 5.1 (3.7 to 26.3) |
< 0.001 |
|
GH, pg/mL |
1590.1 ± 2447.5 (34.8 to 13708.0) |
6495.4 ± 9072.2 (30.7 to 34811.5) |
0.002 |
|
FSH, mIU/mL |
3.8 ± 2.0 (0.8 to 8.1) |
5.7 ± 3.7 (0.6 to 16.4) |
NS |
|
LH, mIU/mL |
1.4 ± 1.7 (0.1 to 7.1) |
2.5 ± 2.5 (0.1 to 11.8) |
NS |
|
TSH, μIU/mL |
3.6 ± 1.4 (1.0 to 7.4) |
3.3 ± 2.2 (0.3 to 11.2) |
NS |
|
PRL, ng/mL |
20.9 ± 9.1 (4.4 to 38.0) |
25.2 ± 14.0 (8.2 to 66.9) |
NS |
|
Cortisol, ng/mL |
58.3 ± 25.3 (16.8 to 116.8) |
74.2 ± 20.0 (23.5 to 101.5) |
0.004 |
|
|
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|
aValues are expressed as mean ± SD(range). Abbreviations: BMI, body mass index; ADI-R, Autism Diagnostic Interview-Revised; WISC-III, the third edition of the Wechsler Intelligence Scale for Children; IQ, intelligence quotient; ACTH, adrenocorticotropic hormone; GH, growth hormone; FSH, follicle-stimulating hormone; LH, luteinizing hormone; TSH, thyroid-stimulating hormone; PRL, prolactin; NS, not significant. |
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|
Iwata et al. Molecular Autism 2011 2:16 doi:10.1186/2040-2392-2-16 |
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