Table 3 |
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|
Clinical and behavioral characteristics of autism spectrum disorder facial subgroups |
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|
Characteristics |
Subgroup 1 n = 12 (18.8%) |
P value |
Subgroup 2 n = 5 (7.8%) |
P value |
Remainder n = 47 (73.4%) |
|
|
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|
Diagnosis |
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|
Autistic disorder |
↑75% |
ns |
↓20% |
ns |
62% |
|
Asperger syndrome |
↓8% |
0.05* |
↑60% |
0.05* |
32% |
|
PDD-NOS |
17% |
ns |
20% |
ns |
6% |
|
Autism course |
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|
Regression |
↑58% |
0.03* |
↓20% |
ns |
25% |
|
Autism severity |
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|
SCQ lifetime, mean (SD) |
↑25.3 (3.2) |
0.03*, 0.05** |
↓17.7 (9.2) |
0.03*** |
20.5 (7.6) |
|
SCQ <15 |
↓0% |
ns |
↑50% |
ns |
24% |
|
IQ scores |
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|
FSIQ, mean (SD) |
78.4 (26.9) |
ns |
96 (36.2) |
ns |
87.9 (20.5) |
|
FSIQ, range |
36 to 113 |
ns |
38 to 127 |
ns |
31 to 130 |
|
FSIQ <70 |
50% |
0.002** |
↓20% |
ns |
15% |
|
FSIQ ≥70 |
50% |
ns |
80% |
ns |
85% |
|
VIQ, mean (SD) |
78.4 (26.9) |
ns |
87.4 (39.2) |
ns |
87.5 (24.6) |
|
VIQ, range |
13 to 122 |
ns |
23 to 121 |
ns |
28 to 138 |
|
VIQ <70 |
42% |
ns |
20% |
ns |
24% |
|
VIQ ≥70 |
58% |
ns |
80% |
ns |
76% |
|
NVIQ, mean (SD) |
79.2 (28.6) |
ns |
↑101.6 (31.0) |
ns |
90.3 (18.5) |
|
NVIQ range |
34 to 119 |
ns |
53 to 121 |
ns |
33 to 129 |
|
NVIQ <70 |
↑45% |
0.02** |
↑20% |
ns |
12% |
|
NVIQ ≥70 |
55% |
ns |
↑80% |
ns |
88% |
|
Language |
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|
Mean age at first word month (SD) |
15 (6.1) |
ns |
↓11.4 (4.3) |
ns |
18.6 (11.0) |
|
Mean age at first phrase month (SD) |
40 (31.5) |
ns |
23.2 (18.2) |
ns |
32.8 (16.5) |
|
Behaviors |
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|
CBCL total problems t-score ≥65 |
↓10% |
0.01** |
25% |
ns |
55% |
|
Physical |
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|
Macrocephaly |
↓17% |
0.02* |
↑80% |
0.02*, 0.02** |
23% |
|
Medical |
|||||
|
GI problems |
33% |
ns |
↑80% |
ns |
36% |
|
Neurological |
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|
Seizures |
33% |
0.07** |
0% |
ns |
11% |
|
Infant feeding problems |
8% |
0.01** |
↑40% |
ns |
51% |
|
Family history |
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|
SRS mother, mean (SD) |
↑43 (21.4) |
0.02** |
25 (10.7) |
ns |
26.2 (20.4) |
|
|
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|
CBCL = Child Behavior Checklist; FSIQ = Full Scale IQ; GI = gastrointestinal; IQ = intelligence quotient; ns = not significant; NVIQ = Non-Verbal IQ; PDD-NOS = pervasive developmental disorder not otherwise specified; SCQ = Social Communication Questionnaire; SRS = Social Responsiveness Scale; VIQ = Verbal IQ. *Subgroups 1 and 2 comparisons. **Comparison of subgroups to the remainder. |
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|
Aldridge et al. Molecular Autism 2011 2:15 doi:10.1186/2040-2392-2-15 |
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