Resolution:
## Figure 3.
Genome scan results of quantitative Social Responsiveness Scale (SRS) scores using
MCLINK. The nonparametric analysis (a) does not assume a genetic model, and scores were
converted to logarithm of odds (LOD) scores for ease of comparison. The parametric
analysis (b), assumes the penetrance vector for an individual is based on their observed
trait value and three specified trait distributions for the three genotypes at the
disease locus (no risk allele, one risk allele, two risk alleles). These trait distributions
are assumed to map onto the SRS score cutoffs (unaffected, spectrum, and affected).
The penetrance vector for an individual is the relative probabilities of the trait
being observed from the three distributions.
Coon |