Molecular Autism


Open Access Highly Access Research

Polymorphisms in leucine-rich repeat genes are associated with autism spectrum disorder susceptibility in populations of European ancestry

InĂªs Sousa1, Taane G Clark1,2, Richard Holt1, Alistair T Pagnamenta1, Erik J Mulder3, Ruud B Minderaa3, Anthony J Bailey4, Agatino Battaglia5, Sabine M Klauck6, Fritz Poustka7, Anthony P Monaco1* and International Molecular Genetic Study of Autism Consortium (IMGSAC)

Author Affiliations

1 Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford OX3 7BN, UK

2 Departments of Epidemiology and Public Health, and Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, London WC1E 7HT, UK

3 Department of Psychiatry, Child and Adolescent Psychiatry, University Medical Center Groningen, PO Box 660, 9700 AR Groningen, the Netherlands

4 University Department of Psychiatry, Warneford Hospital, Oxford, UK

5 Stella Maris Clinical Research Institute for Child and Adolescent Neuropsychiatry, Calambrone (Pisa), Italy

6 Division of Molecular Genome Analysis, German Cancer Research Center, Heidelberg, Germany

7 Department of Child and Adolescent Psychiatry, Johann Wolfgang Goethe-University, Frankfurt/Main, Germany

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Molecular Autism 2010, 1:7 doi:10.1186/2040-2392-1-7

Published: 25 March 2010

Additional files

Additional file 1:

TDT results for the single nucleotide polymorphisms genotyped across LRRTM1, LRRN1, LRRN3 and LRRTM3 genes in the singleton families of the International Molecular Genetic Study of Autism Consortium population.

Format: XLS Size: 27KB Download file

This file can be viewed with: Microsoft Excel Viewer

Open Data

Additional file 2:

TDT results for the single nucleotide polymorphisms genotyped across LRRTM1, LRRN1, LRRN3 and LRRTM3 genes in the Northern Dutch population.

Format: XLS Size: 27KB Download file

This file can be viewed with: Microsoft Excel Viewer

Open Data

Additional file 3:

TDT results for the single nucleotide polymorphisms genotyped across LRRTM1, LRRN1, LRRN3 and LRRTM3 genes in the multiplex families of the International Molecular Genetic Study of Autism Consortium population.

Format: XLS Size: 27KB Download file

This file can be viewed with: Microsoft Excel Viewer

Open Data

Additional file 4:

TDT results for the single nucleotide polymorphisms genotyped across LRRTM1, LRRN1, LRRN3 and LRRTM3 genes in the Italian population.

Format: XLS Size: 27KB Download file

This file can be viewed with: Microsoft Excel Viewer

Open Data

Additional file 5:

TDT results for the single nucleotide polymorphisms genotyped across LRRTM1, LRRN1, LRRN3 and LRRTM3 genes in the German population.

Format: XLS Size: 26KB Download file

This file can be viewed with: Microsoft Excel Viewer

Open Data

Additional file 6:

TDT Meta-analysis results for the single nucleotide polymorphisms genotyped across LRRTM1, LRRN1, LRRN3 and LRRTM3 genes.

Format: XLS Size: 27KB Download file

This file can be viewed with: Microsoft Excel Viewer

Open Data