Table 2 |
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|
Results of univariate and adjusted unmatched analyses. |
||||||
|
Univariate analysis |
Adjusted analysis |
|||||
|
|
||||||
|
Variable |
Cases |
Cohort Comparisons |
p-value |
Odds ratio (95% confidence interval) |
p-value |
Odds ratio (95% confidence interval) 1 |
|
|
||||||
|
Fathers' age |
||||||
|
19-24 |
10 |
53497 |
.267 |
0.679 (0.343-1.344) |
0.796 |
0.912 (0.453-1837) |
|
25-29 |
47 |
170796 |
Ref. |
|||
|
30-34 |
57 |
167541 |
.282 |
1.236 (0.840-1.819) |
0.832 |
1.046 (0.690-1.586) |
|
35-39 |
38 |
95519 |
.091 |
1.446 (0.943-2.217) |
0.167 |
1.435 (0.860-2.395) |
|
=> 40 |
27 |
62001 |
.057 |
1.583 (0.986-2.541) |
0.023 |
2.026 (1.100-3.728) |
|
Mothers' age |
||||||
|
13-19 |
7 |
43320 |
.189 |
0.587 (0.265-1.299) |
0.442 |
0.727 (0.324-1.636) |
|
20-24 |
47 |
170732 |
Ref. |
|||
|
25-29 |
63 |
167423 |
.105 |
1.367 (0.937-1.994) |
0.528 |
1.143 (0.775-1.731) |
|
30-34 |
43 |
108886 |
.087 |
1.435 (0.949-2.170) |
0.699 |
1.108 (0.659-1861) |
|
=> 35 |
19 |
58993 |
.564 |
1.170 (0.687-1.993) |
0.636 |
0.846 (0.422-1.694) |
|
Fathers' education* |
||||||
|
Graduate |
64 |
69656 |
Ref. |
|||
|
High school |
53 |
153123 |
.000 |
. 323 (.224-. 464) |
0.009 |
0.578 (0.383-0.873) |
|
Primary/middle school |
48 |
288446 |
.000 |
.155 (.107- .226) |
0.004 |
0.462 (0.273-0782) |
|
No education |
14 |
48129 |
.000 |
.271 (.152- .483) |
0.984 |
0.992 (0.430-2.289) |
|
* Mothers' education |
||||||
|
Graduate |
55 |
40106 |
Ref. |
|||
|
High school |
57 |
155404 |
.000 |
.267 (.185 - .387) |
0 |
0.438 (0.284-0.674) |
|
Primary/middle school |
51 |
281892 |
.000 |
.132 (.090- .193) |
0.001 |
0.390 (0.222-0685) |
|
No education |
16 |
71952 |
.000 |
.162 (.093- .283) |
0.101 |
0.488 (0.207-1.152) |
|
Birth order |
||||||
|
First born |
99 |
239361 |
Ref. |
|||
|
Second |
48 |
160025 |
0.068 |
.725 (.514 - 1.024) |
0.05 |
0.681 (0.464-1.000) |
|
Third & higher |
32 |
149968 |
0.001 |
.516 (.346 - .769) |
0.016 |
0.515 (0.300-0.884) |
|
Sex |
||||||
|
Female |
36 |
266124 |
Ref. |
|||
|
Male |
143 |
283230 |
.000 |
3.732 (2.590-5.379) |
0 |
3.358 (2.607-5.417) |
|
Consanguinity†|
||||||
|
not related |
121 |
382301 |
0.562 |
1.097 (0.802-1.500) |
0.003 |
1.639 (1.182-2.274) |
|
related |
58 |
167053 |
Ref. |
|||
|
Urban/Rural |
||||||
|
Rural |
4 |
115499 |
.000 |
.086 (0.032-.0231) |
0.001 |
0.163 (0.059-0.454) |
|
Urban |
175 |
433855 |
Ref. |
|||
|
|
||||||
|
* Graduate indicates college graduate up to and including graduate degrees. High school indicates high school graduate up to associate's degree (2 years college); primary/middle school indicates any education up to but not including high school. †Consanguinity (scored dichotomously) indicates that the parents are closely related, as either first, second or third cousins. |
||||||
|
Sasanfar et al. Molecular Autism 2010 1:2 doi:10.1186/2040-2392-1-2 |
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