Haploinsufficiency of the autism-associated Shank3 gene leads to deficits in synaptic function, social interaction, and social communication
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* Corresponding author: Joseph D Buxbaum joseph.buxbaum@mssm.edu
- † Equal contributors
Molecular Autism 2010, 1:15 doi:10.1186/2040-2392-1-15
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Following the genes: a framework for animal modeling of psychiatric disorders Kevin J Mitchell, Z Josh Huang, Bita Moghaddam, Akira Sawa BMC Biology 2011, 9:76 (11 November 2011) This article is part of a collection on Wiring the brain Following a brief overview of the revolution in psychiatric genetics, Kevin Mitchell and colleagues explain how the effects of causal mutations can be studied in animals to elucidate pathogenic mechanisms and neurobiological phenotypes of direct relevance to human disease.
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